Mouse Gene Aoc1 (ENSMUST00000162948.6) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default) (2024)

Mouse Gene Aoc1 (ENSMUST00000162948.6) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)

Description: Mus musculus amine oxidase, copper-containing 1 (Aoc1), transcript variant 1, mRNA. (from RefSeq NM_001161621)
Gencode Transcript: ENSMUST00000162948.6
Gencode Gene: ENSMUSG00000029811.14
Transcript (Including UTRs)
Position:mm10 chr6:48,904,986-48,909,187Size:4,202Total Exon Count:4Strand:+
Coding Region
Position:mm10 chr6:48,905,192-48,908,833Size:3,642Coding Exon Count:4

Page Index	Sequence and Links	UniProtKB Comments	Primers	RNA Structure	Protein Structure
Other Species	GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information
Methods

Data last updated at UCSC:2019-09-20

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:48,904,986-48,909,187)			mRNA (may differ from genome)		Protein (756 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Table Schema	AlphaFold	BioGPS
Ensembl	Entrez Gene	ExonPrimer	GeneCards	MGI	PubMed
Reactome	SOURCE	UniProtKB

Comments and Description Text from UniProtKB


	ID: E9PYN9_MOUSE DESCRIPTION: RecName: Full=Amine oxidase; PTM: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue (By similarity). SIMILARITY: Belongs to the copper/topaquinone oxidase family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

Primer design for this transcript


	Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Click here to load the transcript sequence and exon structure into Primer3Plus Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. Click here to open Exonprimer with this transcript To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-67.90	206	-0.330	Picture	PostScript	Text
3' UTR	-92.80	354	-0.262	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000269 - Cu_amine_oxidase
IPR015798 - Cu_amine_oxidase_C
IPR016182 - Cu_amine_oxidase_N-reg
IPR015800 - Cu_amine_oxidase_N2
IPR015801 - Cu_amine_oxidase_N2/3
IPR015802 - Cu_amine_oxidase_N3

Pfam Domains:
PF01179 - Copper amine oxidase, enzyme domain
PF02727 - Copper amine oxidase, N2 domain
PF02728 - Copper amine oxidase, N3 domain
PF09248 - Domain of unknown function (DUF1965)

SCOP Domains:
88645 - ssDNA viruses
49998 - Amine oxidase catalytic domain
54416 - Amine oxidase N-terminal region

ModBase Predicted Comparative 3D Structure on E9PYN9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Human	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	Genome Browser	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
	RGD
	Protein Sequence
	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005507 copper ion binding GO:0008131 primary amine oxidase activity GO:0016491 oxidoreductase activity GO:0046872 metal ion binding GO:0048038 quinone binding Biological Process: GO:0009308 amine metabolic process GO:0055114 oxidation-reduction process

Descriptions from all associated GenBank mRNAs


	BC021880 - Mus musculus amiloride binding protein 1 (amine oxidase, copper-containing), mRNA (cDNA clone MGC:28601 IMAGE:4216952), complete cds. AK144567 - Mus musculus adult male intestinal mucosa cDNA, RIKEN full-length enriched library, clone:G630098L19 product:amiloride binding protein 1 (amine oxidase, copper-containing), full insert sequence. BC034215 - Mus musculus amiloride binding protein 1 (amine oxidase, copper-containing), mRNA (cDNA clone MGC:37618 IMAGE:4989866), complete cds. AK146078 - Mus musculus 11 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530028M11 product:amiloride binding protein 1 (amine oxidase, copper-containing), full insert sequence. BC022627 - Mus musculus amiloride binding protein 1 (amine oxidase, copper-containing), mRNA (cDNA clone IMAGE:4205497), partial cds. AK005423 - Mus musculus adult female placenta cDNA, RIKEN full-length enriched library, clone:1600012D06 product:amiloride binding protein 1 (amine oxidase, copper-containing), full insert sequence.

Biochemical and Signaling Pathways


	KEGG - Kyoto Encyclopedia of Genes and Genomes mmu00330 - Arginine and proline metabolism mmu00340 - Histidine metabolism mmu00380 - Tryptophan metabolism Reactome (by CSHL, EBI, and GO) Protein E9PYN9 (Reactome details) participates in the following event(s): R-MMU-6798749 Exocytosis of specific granule lumen proteins R-MMU-5696131 AOC1 deaminates Hist R-MMU-6798695 Neutrophil degranulation R-MMU-211945 Phase I - Functionalization of compounds R-MMU-168249 Innate Immune System R-MMU-211859 Biological oxidations R-MMU-168256 Immune System R-MMU-1430728 Metabolism

KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00330 - Arginine and proline metabolism
mmu00340 - Histidine metabolism
mmu00380 - Tryptophan metabolism

Reactome (by CSHL, EBI, and GO)

Protein E9PYN9 (Reactome details) participates in the following event(s):

R-MMU-6798749 Exocytosis of specific granule lumen proteins
R-MMU-5696131 AOC1 deaminates Hist
R-MMU-6798695 Neutrophil degranulation
R-MMU-211945 Phase I - Functionalization of compounds
R-MMU-168249 Innate Immune System
R-MMU-211859 Biological oxidations
R-MMU-168256 Immune System
R-MMU-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: Abp1, E9PYN9, E9PYN9_MOUSE, NM_001161621, uc009bwb.1, uc009bwb.2 UCSC ID: uc009bwb.2 RefSeq Accession: NM_001161621 Protein: E9PYN9CCDS: CCDS51767.1

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

Mouse Gene Aoc1 (ENSMUST00000162948.6) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default) (2024)

References